Run a lot, especially HQ. And by a lot I mean you want at least 1 successful run every turn. Several cards reward successful runs, the breakers are all efficient and you have tools to go around defences.
Paragon - Excellent reward for successful runs. Ideally you want to install this ASAP. Synergy with John Masanori. Note: as of time of writing jnet has a bug with Paragon + John. You should be able to choose the order in which the cards resolve but currently they always resolve in the order they were installed.
R&D Interface - Late game card making your R&D, runs more efficient and locking the corp.