If you played with this kind of deck, such as labbes' one, you'll know that the biggest problem is sniping GT on R&D.
But you know her? Shannon Claire! She can hide your GT plan on the bottom of R&D, then you'll never worry about those lucky snipers. Sweet.
Annnnd another good news. You can use 2-3rd copy of her to hide 'another' agendas underneath GT or something!
'Hey, I think you are missing that Shannon Claire shuffles your deck......"
Yes, Shannon shuffles your deck, but you need to read her more carefully.
'Search R&D or Archives for an agenda and reveal it. Shuffle the rest of R&D if you searched it.'
So if your agenda was in Archive, Shannon won't shuffle. It means we can keep our GT in bottom. It means we can keep 2 more agendas in bottom. It means you'll have only 6~7 points available in runner's accessible position. It makes you never lose your game.
Oh, and one last thing. Preemptive shuffles your deck. Use it only when your central is safe enough.