Pros

• her bypass ability makes her very flexible because you can target a non-Sentry
• her bypass ability also circumvents "when encountered" abilities, so Tollbooth, Data Raven, and Komainu make prime targets.
• you can also target unrezzed Ice, if you have a strong read on your opponent what kind of ICE he is hiding there.
• easily splashable with only one influence point.

Cons

• most expensive breaker in the game as far as installing cost
• quite expensive to boost her strength
• Be aware that the corp can "revive" a femmed piece of Ice with Chum. Now you've got to break Chum, if you intend to bypass the Ice without taking Net damage.

Thoughts

• seems to be a very strong breaker for Shapers. Not only do they have the "weakest" Killers, they have plenty of tools to take advantage of Femme:
  • Test Run allows you to bypass a certain piece of Ice without paying the 9 credits upfront and you can then choose a different target once you install her "for real"
  • Personal Workshop allows you to take advantage of the timing structure as you can install your Femme during a run after an approached piece of ICE gets rezzed
  • With her high pumping, but good breaking cost makes her a prime target for Shapers strength boosting equipment, e.g. a Femme Fatale on a Dinosaurus is a very efficient breaker against most sentries.
• Could work in an Anarch deck with Personal Workshop to get into a certain central server you want to hammer

Along with Bukhgalter, Femme Fatale is the second iconic sentry breaker of the game.

Yes, it is the MOST expensive breaker in the game also. Upon installation, it will make an ice trivial to pass. Some ice can remain expensive to pass (Mausolus and Ansel 1.0 would cost 3 and Masvingo can be made way too expensive). But it make some ice worthless (Tollbooth and Funhouse for example).

The best support card for Femme Fatale is Rejig. Allowing you to change its ice placement (or to reinstall it after the corp trashed the ice it was on).

Other good support for its sentry breaking ability are Takobi and Leech. Each point of strength that you lower is essentialy 2 saved, that is good value.

But the fact remain that for the install cost, it is seldom worth it to play (aside from the fact that it cost 1 influence).

Of note, Tāo Salonga: Telepresence Magician can create immense value out of this card, since the ice on which it has been installed can be placed in the most advantageous position.

Don't despair, there are plenty of support for that part.

For shaper, Compile and Test Run will let you use it for cheap. Compile is especially good here, since you need only a single copy of Femme Fatale to be able to bypass for cheap any ice and still be able to break a sentry. This give you something like Inside Job but without the influence cost.

For anarch (and other runner), Retrieval Run will allow you to install it for free. The value here is tremendous!

Fro criminal, there is Credit Kiting, allowing you to get great value out of it also.

As can be seen, using Femme Fatale require you to think more about your deckbuilding decision, since the card need support. But anytime it comes on the board, you'll see the corp eyes pop open and sweat start to drip.

Iconic art, iconic quote, just iconic to the game.