Ultimate Project Ares

Overkill Advance. Advance Haas Arcology AI, then begin to score out an agenda. If you have your first Efficiency Committee or Mandatory Upgrades scored, you're unstoppable. The following combo takes a lot of credits and clicks, but can be used by the best players to assert dominance over their opponents (keep in mind it becomes better if you have one or more Mandatory Upgrades scored!). Here's how you make the runner weep:

1. Install Project Ares (2 clicks left)
2. Biotic Labor (3 clicks left)
3. Biotic Labor (4 clicks left)
4. Take a token from Haas Arcology AI to gain another click (5 clicks left)
5. Take a token from your second Haas Arcology AI (6 clicks left)
6. Advance Project Ares 4 times (2 clicks left)
7. Use tokens from Efficiency Committee (4 clicks left)
8. Play Shipment from SanSan to advance Project Ares 4 times
9. Score Project Ares to make the runner trash 4 (!!!!!) cards.
10. Bask in your glory

Backup plan: Pray the runner faceplants into Merlin and you can flatline him.