Hit runner with brain damage and then flatline with net damage.
Of course flatlining is not the only win condition - with the consistency of 45-cards deck, a lot of economy and great ICE it's very easy to win through agendas.
You also have some nice traps like Snare, Cerebral Overwriter or Aggressive Secretary - so the runner never knows what can hit him.
And if the Atmans are too much trouble, there's Corporate Troubleshooter to protect your server.