After a lengthy back and forth with Lysander as he was developing his Astrobiotics list, I managed to get mine down to 40 cards. I kept Jackson around because there are Noise players in my meta, but you can cut 2x Jackson for Shipment from SanSan, Enigma, or Chimera.
I stuck with 3x Biotic Labor because I always want to have one in hand. That way my SanSan City Grids are pure Runner tax, rezzed only if the Runner declines to trash them -- basically if they can't afford it. If left around, it's easy to score a Profiteering for 10c and set up the next Beale. (This assumes you have failed to get on the Astrotrain; if you're on the Astrotrain, just ride that to victory -- it's definitely Plan A.)
Tollbooth is the emergency protection against R&D lock, or ice for a scoring remote against non-Criminals if you get in a position where you have to create one.
As always, time your Grim rezzes very carefully. The bad pub adds up; if it isn't going to open a scoring window, don't do it.