I love this agenda. I'm mainly playing it in a Jinteki fast advance deck with Tennin Institute: The Secrets Within Identity. It combos nicely with Shi.Kyū which I put in archives as soon as it shows up. As the runner tends to run on unprotected archives not to trigger the Identity, he/she will sooner or later take it as an -1 agenda.

In addition I tend to surrender one copy of Medical Breakthrough to make the others scorable from hand. That makes for a decent amount of net damage once Philotic Entanglement is scored (with Trick of Light).

The obvious drawback is that it can take some time and card draw until you come up Philotic Entanglement at just one copy per deck.