Startup+ is a format in which you are allowed to take one Sandard legal ID and a playset.
The great plan here is to force the runner to decide if he wants to eat the damage or let you score. La Costa Trap or Agenda and one ICE in front of it save the Centrals with Otoroshi and then hope for no Botulus. When the runner isn't testing the waters or you are ballsy enough just kill the runner with Clearinghouse. If found early you can force the runner to just look at every nasty thing you put down.