This is Nisei MK II in upgrade form. It is right there with Border Control in server denial. In Glacier, it is powerful, making the runner go through ice just to get an end the run as they pass the last ice. But it get even better. You can give an end the run for ANY server on the board. All for the cost of 2 advancements.

Bio Vault pair very well with La Costa Grid, so that it get its tokens for free. It is much more versatile (and cheaper) than Border Control, but will cost more tempo (1 click to install, 2 clicks to advance). And for one influence less, it can be splashed anywhere.

In fact, Bio Vault is so good that it is a trash on sight for runners. Any runner who see an unrezzed upgrade with two advances, knows it will take much more effort to get in that server.