I can only think of the combo with Keegan Lane. If the runner decides to continue the run after passing the last ice, rez keegan lane in step 4.3 and the runner loses a tag and a program. Lock them out in Skorpios.

That combo only works once due to the runner trashing Lynn and/or Lane. And it requires some luck to get both pieces in place at the right time, especially considering both can be sniped from HQ. —
Sure the combo works only once - Lane's ability requires you to trash him in order to trash a program... —
True, missed that. But it just makes it even easier for the runner to trash Lynn as well to make the combo double as hard to pull off again. —
Friends in High Place can resolve the 2 card combo easily. —