Obviously, this card is very important for Adam: Compulsive Hacker, lending him a great deal of early HQ aggression and in faction, turn one multi access. But there is something that really bugs me about it's design: influence cost.

There already exists an HQ multi access card: HQ Interface. It only costs two influence and has no drawbacks. Now, a runner might be inclined to use NAT and deal with the drawbacks of the card if the influence were lower than HQI. But that's not the case. I can't think of any reason why a objectively less powerful card in any other faction would cost more influence to import except for flavor. I'm assuming that was the design choice here: having Bioroid technology and programming in your human brain isn't something you can just peddle off the streets. You need some connections for that, so it costs more influence. Also, it makes it consistent with the influence cost of the other two directives. So unfortunately, what could have been an interesting choice to make in deckbuilding becomes a card you only want in one place. Ever.

Clearly, these mini faction cards are best suited to the Runner's they belong to, but there are a handful of new Runner cards that are great additions to other factions. Unfortunately, Neutralize All Threats is one of those situations where the flavor and the mechanics of a card clash.

Adam ALWAYS takes this directive. It is that good. Sadly, nobody import it in their deck. Especially now that Docklands Pass is easily available for one influence less, 2 more and an hardware. Maybe Zahya Sadeghi: Versatile Smuggler could use Neutralize All Threats to make a cool 3 when breaching HQ (by a direct run or with Sneakdoor Beta). Otherwise, it is simply not worth it.

With this directive, Adam can control HQ from the start of the game, making Adam a very aggressive runner.

Of course, this pairs well with Sneakdoor Beta, especially since this is a "whenever" ability. Allowing you to (probably) see the whole of HQ in one turn, if you run about three times with Sneakdoor Beta or directly.

The art is nice but I fail to see the relation with neutralizing threats or accessing more cards. At least the name relate to the effect of the card. The quote gives us a good bit of lore about bioroids. Good enough for me.

It apparently hasn't been said yet, but this card is absolutely brutal when paired with Gang Sign. Each time the Corp scores an agenda, you get a two card access from HQ, and that's only with ONE Gang Sign. Multiple signs will trigger in succession, each time granting you two accesses with NAT. The 'cost' of trashing the first trashable card you access each turn is negligible, since you're probably playing Criminal or Anarch and subsequently rolling in dough or scrubbing / imping the Corp anyway, respectively. And you really should be trashing any and all corp cards you can in the first place, if for no other reason than to reduce the odds you'll access the same card(s) again.

Also, it costs 0 and, as WayneMcPain points out, is only three influence. I fully expect to see NAT in a Leela Gang Sign deck.