My first thought on reading this card was, “Wow, that is insanely good.” And indeed is has quite a few comely attributes. The one problem though is Paperclip. Paperclip is a ridiculously good card, probably the best breaker in the game. I feel comfortable saying that it makes an appearance in most runner decks. Paperclip breaks this for just four. That is quite low for a piece of ICE with a rez cost of nine. Still, that will add up over time.
Now that that is out of the way, lets talk about the many perks of Tithonium.
-Tithonium is the fifth ICE immune to Parasite! Caissas and Egret too. This while still being about to host "cards" like Oversight AI, Rover Algorithm, and Sub Boost. Certainly a nice bonus.
-Tithonium is a Destroyer Barrier. Its mere existence forces the runner to have all three breakers or a solid A.I. in play before running or risk serious repercussions, in this case losing up to two programs and a resource. Bulwark is not nearly as painful.
-Tithonium can be rezzed by forfeiting an agenda instead of paying its rez cost. Use this if you are short on credits, are playing Jemison, or have a scored Standoff.
Other niceties are the fact that it is immune to Endless Hunger, it only costs two influence and that the card is named after a big @ss canyon on Mars.
Watch out for Knifed, Sharpshooter, and derez effects.