If you're passing on a blank 3/2 like Project Yagi-Uda, I'd pass on this as well. Yes, it allows you to free up a deck slot that might have otherwise gone to Preemptive Action or Spin Doctor, but that isn't much value. I'd appraise Longevity Serum's ability at ~2 credits of value. In contrast, the other 1-copy-only agendas have unique effects which aren't easily replaced by a 0-cost card.

I would only choose this card in decks where trying to score 4/2s would be too hard (e.g. PE). If you can score 4/2s, it doesn't make sense to cut a 4/2 to include this card -- any combination of Nisei Mk 2, Cyberdex Sandbox, Corporate Sales Team, Viral Weaponization, and Offworld Office are much stronger.

This is the replacement for Philotic Entanglement, from the past meta. In my opinion, it is the weakest if the 2/3 agendas which have a limit of 1 per deck.

It is better than Project Yagi-Uda, whose secondary effect has almost never be seen in play, because it basically act like an instant Preemptive Action, with the possibility to trash card from HQ so that you may put them back in R&D, like if you are flooded with agendas.

This is why it is a worthwhile agenda for Jinteki, allowing you to have 7 agendas in a 49 cards deck (6 3-pointers and 1 Longevity Serum).

There are layers of art in this card, with layers of flavor, along with the quote. Nicely done.