What an upgrade this is! With all the fast advance tools in the HB faction, scoring an agenda with Djupstad Grid is pretty easy, if expensive. Without Caldera or Heartbeat, there is no way to avoid the Core Damage.
At 4 to trash, it will have an impact. At 4 to rez, it will cost you a great deal. But this will always work Even better when using Élivágar Bifurcation. This will power up your ability to score Ontological Dependence out of hand. All the while taking a card out of the runner's hand and lowering the runner handsize. A runner might not care too much about one or two Core Damages, but at 3 or 4 Core Damages, it will make the game more difficult. Especially if you have traps in your deck.
Djupstad Grid is the most reliable way to do Core Damage in my opinion. But it is also the most expensive. Also, because it is based on scoring agendas, you will do a maximum of 2 to 3 Core Damages. Most decks wins after scoring 4 agendas. If you want to do more Core Damages, you'll have to use other tools.
But there is an interesting interaction out of faction. If you use Reeducation, once scored, you can take out all the runner's cards and then do the Core Damage, while the runner has no cards in hand. This is a simpler interaction than with Neurospike, for a slightly higher cost. Thus allowing you to reliably kill the runner. Outside this NBN interaction, at 4 influences, it will have to be a core part of a deck strategy to be used. Because for 2 influences, you can get Cerebral Overwriter, which work in many archetypes.
The art show us a city underwater, letting us believe that lethal objects are hidden under the waves. The quote pairs well with the art and gives us a bit of lore, adding that the quote come from Mr. Hendrik, which reflect on the ability of both upgrades. Awesome design!