It does not take a lot of work to put 2 Core Damage on the runner. Half the time, the runner will do it to themselve with cybernetics.

Otherwise, you can use Mr. Hendrik, Nightmare Archive, Djupstad Grid or even Cerebral Overwriter. You could use also Hypoxia, but it is more difficult. There is also Thule Subsea: Safety Below that can incite the runner to take Core Damage. Also, there are ices like Bloop, Fairchild 3.0, Hákarl 1.0 and Tyr that can also do it.

More often than not, this will be a 2-2 agenda, with little effort. Against Esâ Afontov: Eco-Insurrectionist, it can even be a 2 points agenda costing 0!

I like the quote a lot and the art is beautiful. I expect this agenda to see a lot of play.