Many cards get touted as Hedge Funds #4 – 6 and this card just gets added to that list. At 1 influence, it will see play anywhere, including the mini-factions, and is a great way to turn off a pesky resource that has overstayed its welcome such as Drug Dealer, Stim Dealer, Lewi Guilherme, or even Always Be Running. This card can also work on any normal self-trashable resource such as Crowdfunding, Armitage Codebusting, or Daily Casts. For that reason, Isolation won’t see much play in decks that already run Aesop's.
For the most part, Isolation is definitely a vanilla economy card – and that’s OK. Remember to factor in the install cost of the resource trashed. You wouldn't want to find yourself having played a crappy Lucky Find.
Most importantly though, can we take a moment to appreciate the flavour of this card? What happened to Hoshiko? Have they always been alone? Did they murder someone close to them to get these hard-earned credits? Are they now suffering from the guilt and burden of – no? Oh, okay.