DDoS Leela - Looking for Feedback

If you're running Desperado, I'd probably change the 2x Armitage Codebusting into 2x Dirty Laundry.

Seeing Leela hit the board is going to make the corp play slower, often making sure they double-ice their centrals (they already should have been double-icing their remotes for Inside Job). This is exactly the kind of play that Gang Sign punishes, and it's much better earlier than later. I'd strongly recommend trying to fit a third one in to make sure you saw it early - maybe -1 Legwork (since you already have the HQ Interfaces) +1 Gang Sign.

With DDoS and Sneakdoor Beta on the board, you're pressuring every single server to an obscene degree. If you want to actually use that pressure to run, you might think about dropping the Gang Sign/HQ Interface suite for something more aggressive (more Legworks at least). Alternatively, if you're going to just turtle and threaten with the Gang Signs, then Desperado might honestly not be the best console (consider Logos or even Turntable).