If you're passing on a blank 3/2 like Project Yagi-Uda, I'd pass on this as well. It's a uniquely clunky effect for a 3/2 and totally unsuitable for the 3x Spin Doctor role of instantly protecting agendas faster than the runner can react. A 3/2 agenda will never be instant anything.

All of the other unique 3/2s have much stronger abilities which are almost always impactful. Longevity Serum is not much better than blank. And, worst, when you really DO need Longevity Serum's effect, you're probably in a dire flooding situation, usually a hard time to score an agenda safely. Even attempting a Longevity Serum play to clear a flood leaves your extra agendas vulnerable in HQ at least 1 turn longer than they would have been with a Spin Doctor. I think this effect would probably be more suitable for a 2/1 agenda.

I would only choose this card in decks where trying to score 4/2s would be too hard (e.g. Shipment from Tennin decks can use it to recycle Shipment from Tennin back into the deck). If you can score 4/2s, it doesn't make sense to cut a 4/2 to include this card -- any combination of Nisei Mk 2, Cyberdex Sandbox, Corporate Sales Team, Offworld Office, and possibly even Viral Weaponization are stronger.

Note: Longevity Serum might have off-brand use in Ampere. Ampere can only run 1x Spin Doctor and might actually benefit from backup recursion. Ampere also has better access to fast-advance cards and economy than Jinteki has, so a 3/2 is inherently more interesting to Ampere even if the ability isn't always valuable.

It's just past the dawn of the Elevation era (August 2025), and this card is a major player in one of the best decks right now, and since it's been 4 years since the last reviews, this card might be worth some re-assessment - a check up, to see how the Serum is working.

Jinteki has never enjoyed particularly great 3/2s, but without the heavily defensive 5/3s of yesteryear, a scoring pattern with 4 agendas has re-entered the red playbook. It's no longer fundamentally wrong to have 11 or more agendas, and this card sees play - though of course it's still 1 per deck.

One thing we saw in System Gateway was an idea that Jinteki sometimes throws their cards away for advantage, and in the sets since then we saw quite a few cards like that- and, at the time of writing, the most impactful of all, an ID that mirrors MaxX - where acceleration through filtered drawing is everything, but a lot of cards end up in the bin, by the Corp's own design. Including this card, which can give you an additional AU Co. counter if you choose. With the addition of Sabotage from the runner (amongst other tricks), that's a lot of scope for important cards to end up in Archives.

This changes Longevity Serum's place in the Jinteki ecosystem quite a bit - no longer is it a Spin Doctor that is worth points, instead this is a reset button, a renewal - a way of recouping some of the options you sacrificed for progress, returning to old ideas... or bringing back threats the Runner thought they dealt with. The runner can have trashed all 3 copies of a kill card, but if you score this, should you wish it you can bring all 3 murder cards back, and return the runner to the cycle of suffering.

There's one last card worth mentioning with this agenda, possibly saving the best till last - Moon Pool. Because Longevity Serum is a 3/2, you can install it, install Moon Pool, and if you have 2 agendas between HQ or Archives, you can advance and score this, shuffling back a total of 5 cards, at least 2 of which are agendas - an absolutely massive swing.

As a Limit 1 Per Deck agenda, Longevity Serum will always have a fundamental weakness, but its strength shouldn't be ignored - it's not a blank by any means

This is the replacement for Philotic Entanglement, from the past meta. In my opinion, it is the weakest if the 2/3 agendas which have a limit of 1 per deck.

It is better than Project Yagi-Uda, whose secondary effect has almost never be seen in play, because it basically act like an instant Preemptive Action, with the possibility to trash card from HQ so that you may put them back in R&D, like if you are flooded with agendas.

This is why it is a worthwhile agenda for Jinteki, allowing you to have 7 agendas in a 49 cards deck (6 3-pointers and 1 Longevity Serum).

There are layers of art in this card, with layers of flavor, along with the quote. Nicely done.