Hammering R&D with 10 runs per turn.

What in god's name is early bird? I do not think this is a card.

Oh boy, you're missing all the fun Heinrich, Honor and Profit spoilers: http://fantasyflightgames.com/edge_news.asp?eidn=4549

http://www.fantasyflightgames.com/edgenpmsec.asp?eidm=222&esem=1&epmi=s

Assuming there are no ices, there are no thrashable cards and every 5th card is an agenda: Reina's turn begins. Run 1: (Early Bird / 1st click) = 1 card accessed. Run 2 (Early Bird): 1 card accessed. Run 3 (Doppelganger): 4 cards accessed. Run 4 (Joshua B): 7 cards accessed (1 agenda). Run 5 (1st All-nighter): 10 cards accessed (4 new). Run 6 (2nd All-nighter): 13 cards accessed (3 new / 1 agenda); Run 7 (Demolition Run / 2nd click): 16 cards accessed (4 new / 1 agenda / 15 thrashed): Run 8 (3rd click): 19 cards accessed (19 new / 3 agendas). Click 4: Remove 1 Tag. In this scenario you get 6 agendas, look at 34 cards and thrash 15. I'm using this example for a less extreme resolution that is still more than capable of securing a win. I think you would have to swap 1 All-nighter, 1 Early Bird or 1 Doppelganger and 1 Deus Ex for 3 Crescentus to make this 5-to-10-run turn economically feasible.

You can't use more than one Early Bird per turn, though - "first click" is pretty obvious there. Gaining a click doesn't refresh the first click you just spent, it adds another to the end of the queue.

I don't know if that Early Bird comment was directed to me or to temporar. If that was to me, don't worry, the +2 referred in the description means the first click run and the run done with the extra click, not using the card twice.