End of the Line is a rerelease of Scorched Earth, with the condition changing slightly to removing the tag instead of them just needing a tag. Therefore, firing a double EotL is harder than landing a double Scorched Earth. You may want to combo it with other tag damage, like Hypoxia, or damage you can fire at any time, like Angelique Garza Correa. Really just anything you have to drop them to 3 cards without spending the tag. To get the tag, you may want traps like Behold! or Snare!, or aggressive sentry ice like Seraph, or even Pharos If they lack a fracter or are poor. Operations like Public Trail or Oppo Research can get them tags, though both rely on you having an econ advantage, with public trail giving the runner the option to pay 8 to avoid it and Oppo Research needing them to be unable to clear 2 or 4 tags in a single turn to get back to you being able to kill them. So End of the Line requires support, and for you to be either in a winning board state, or a particular losing one.
However, on a personal note, I feel End of the Line is one of the best ways to end a game. Flatlines feel more personal than scoring out to me. I was going to renovate Oaktown whether or not a cyberterrorist decided to cross me, but I, CEO Braganza, took time out of my busy day to coordinate my kill teams to find and eliminate the criminal. End of the Line ends the game with a flourish. You say End of the Line, letting them know their story has come to its conclusion, then pull the trigger. And it's always exhilarating to pull victory from the jaws of defeat, turning their risky run to steal an agenda for an advantage into their final mistake.
Some of us from the old guard see this less as a change, and more as the return. We remember Scorched Earth+SEA Source, and we will never forget.
— HolyMackerel