Along with Bukhgalter, Femme Fatale is the second iconic sentry breaker of the game.
Yes, it is the MOST expensive breaker in the game also. Upon installation, it will make an ice trivial to pass. Some ice can remain expensive to pass (Mausolus and Ansel 1.0 would cost 3 and Masvingo can be made way too expensive). But it make some ice worthless (Tollbooth and Funhouse for example).
The best support card for Femme Fatale is Rejig. Allowing you to change its ice placement (or to reinstall it after the corp trashed the ice it was on).
Other good support for its sentry breaking ability are Takobi and Leech. Each point of strength that you lower is essentialy 2 saved, that is good value.
But the fact remain that for the install cost, it is seldom worth it to play (aside from the fact that it cost 1 influence).
Of note, Tāo Salonga: Telepresence Magician can create immense value out of this card, since the ice on which it has been installed can be placed in the most advantageous position.
Don't despair, there are plenty of support for that part.
For shaper, Compile and Test Run will let you use it for cheap. Compile is especially good here, since you need only a single copy of Femme Fatale to be able to bypass for cheap any ice and still be able to break a sentry. This give you something like Inside Job but without the influence cost.
For anarch (and other runner), Retrieval Run will allow you to install it for free. The value here is tremendous!
Fro criminal, there is Credit Kiting, allowing you to get great value out of it also.
As can be seen, using Femme Fatale require you to think more about your deckbuilding decision, since the card need support. But anytime it comes on the board, you'll see the corp eyes pop open and sweat start to drip.
Iconic art, iconic quote, just iconic to the game.