They should rename this card Murderer of Anarchs.
Depending on how the game is going I'll try not to rez this unless I'm confident I can pick off a runner. I've rezzed 3 Cortex Locks ever, and every time it has flatlined a boistrous Anarch with no breakers installed.
Thanks to Chrome City, the orange bastards are everywhere these days, and for 2 inf this is not a bad splash as a Surprise! sort of card.
In faction it is tasty. Against most Jinteki IDs runners will run on a minimum of 3/4 cards in hand so they don't fall foul to a nasty Snare! If they have 0/ 1 programs installed at the time it can be game over there and then. No one seems to expect it, and if they do they don't seem to account for it when picking their hand size for running. Even if it doesn't kill them, reducing a runner to 0 cards in hand during a run is basically a good ol' Jinteki invisible ETR. In PE, a good deal of what they could then access would kill them, and it's not much more attractive in RP, IG, and so on. If they go down to 0 or even 1 cards they're going to jack out.
Lockdown is another beautiful card. Pop a Lockdown, then Cortex so they can't trigger I've Had Worse or draw up again before your turn, and you can really put the fear of God in them.
Port Anson Grid: Make them carry on running in to your Data Mine! Force them to access the Snare! or Shock! you know is on top of R&D for some reason! Jackson all of your agendas out of Archives before benevolently letting them take 3 Shi.Kyūs for 0 credits! Basically anything where them having to continue the run is going to kill them or set them back significantly.
Neural EMP: Especially in combination with Lockdown. Beep....beep....beep.
You get the idea.
Gets exponentially worse as the game goes on (in most matchups anyway), but a lot of Jinteki ICE is so spiky that it can transition in to a bluff role later on in the game. The uncertainty could buy you then turn you need to score out your winning agenda. Or you could just chuck it in Archives and install something meatier instead.