So the obvious point here is that now that there's a fourth distinct Directive, Adam can choose one of the four to not have to start with. I'm going to be uncontroversial and suggest the best option to skip is probably Safety First, simply because it ironically makes early game runs against Jinteki (and some Weyland/HB builds) a lot more dangerous. You should probably still run Safety First though, because once you've got some other way to shore up your hand size up and running (Brain Chip?) the free draw is really strong. So the main value is in DELAYING Safety First until you're ready to deal with the downside, not getting rid of it entirely.
Now, the card itself. The effect is strong by itself (it's easy to see this from what other things that reveal the top card of R&D like Deep Thought require of you), and I honestly think the downside gets less nasty the better you and your opponent are at Netrunner. If your opponent is good, they'll be able to roughly guess what they need to be defending against ANYWAY based on cues in your initial turns. It's the same reason Expose is often considered a "newbie" thing: Once you get a feel for the game, you can gauge what ICE you need to be prepared to faceplant into without needing it. It does mean you can't pack any nasty surprises into your deck though, unless you work around it with "tutors" like Self-modifying Code. Or by ending the game really quickly.
The other good news is that it synergizes well with Always Be Running and Neutralize All Threats to produce insane levels of early game pressure. You can hit HQ pretty reliably on your first turn (clicking through the ICE if necessary), score a double access, and reveal the top card of R&D to see if you ALSO want to hit that. This is before even considering any cards that you might have in your deck proper! Plus, this card lets you pitch your mandatory run into Archives without feeling too bad if the situation demands it. These two things together put the Corp into a nasty situation on their first turn. They can:
Put no ICE on HQ and take a large risk of losing an Agenda for almost nothing.
Put one ICE on HQ and take the same risk, but knowing that it'll cost clicks to get in if they decide to rez (remember that you can choose to bounce off an ETR if you'd prefer to use your clicks for installation and it still forces them to rez to keep you out, AND if they decide not to rez because they value their creds more than denying you your clicks then you get in for free!)
Put two ICE on HQ and be able to put only one ICE on ONE of the other centrals, meaning the best case is probably that Adam hits an undefended Archives to reveal the top card of R&D, then has time to install breakers before going for it if he wants it. Or you can just open with The Maker's Eye.
Build a remote server. This is risky for the usual reasons, but it's even worse in this case because you can probably get into both the remote and HQ on your first turn now, and if HQ is empty of Agendas then there's a good chance the thing they installed is one. Not to mention that you're still getting to see the R&D top card...
There are answers to this (any multi-ETR early game ICE like Spiderweb, the usual "get Agendas out of HQ" suspects, NAPD Contract and Fetal AI, etc) but most of them require investment on the corp's part which means they're setting themselves back to counter something you're doing for essentially free. This can do one of two things:
Aim to win quickly. In this case the use case is obvious: you can pick up some quick accesses early on, this directive allows you to pressure R&D automatically if you're running other servers (which you should be!), and the downside is even mitigated because your game plan is more straightforward.
Aim to win SLOWLY. In this case, your early pressure buys time for you to get established and helps to shorten the midgame by forcing the corp to commit more stuff to defending centrals rather than scoring out (or if they ignore the pressure, it gives you a good chance at a point advantage). Not starting with Safety First installed also makes it harder for you to get flatlined before you can make it to endgame, and the informational advantage of getting to see some of the cards the Corp is getting shouldn't be underestimated either.
In summary, I think the main reason not to start with this card installed instead of Safety First will be if you want to surprise your opponent with something or you're playing a certain type of event-heavy deck (where the clickless draw from Safety First is so valuable that it's worth giving up the R&D pressure on offer here). Since Adam's signature console lets him snowball games (i.e. KEEP winning if he STARTS winning), a free tool to help you start winning is powerful. You COULD replace other Directives instead and in some cases this is important (Industrial Genomics: Growing Solutions makes Neutralize All Threats a huge liability, for example), but you can make this decision after seeing what your opponent's ID is! This also means you can take Safety First instead if you judge that it will be safe enough.
Now what about using it in other factions? Eh, probably not. It's too much influence and it loses a lot of its appeal if you're not starting with it installed (meaning you have to find it and it essentially costs a click to draw)
