Adam ALWAYS takes this directive. It is that good. Sadly, nobody import it in their deck. Especially now that Docklands Pass is easily available for one influence less, 2 more and an hardware. Maybe Zahya Sadeghi: Versatile Smuggler could use Neutralize All Threats to make a cool 3 when breaching HQ (by a direct run or with Sneakdoor Beta). Otherwise, it is simply not worth it.
With this directive, Adam can control HQ from the start of the game, making Adam a very aggressive runner.
Of course, this pairs well with Sneakdoor Beta, especially since this is a "whenever" ability. Allowing you to (probably) see the whole of HQ in one turn, if you run about three times with Sneakdoor Beta or directly.
The art is nice but I fail to see the relation with neutralizing threats or accessing more cards. At least the name relate to the effect of the card. The quote gives us a good bit of lore about bioroids. Good enough for me.
This card basically rotated when Find the Truth was printed.
— Greasythumb