In a meta where ice is of questionable value, dominated by Endurance and Boomerang and Botulus and other ways to sidestep costs to the runner, the corp is incentivized to pivot to a different way to tax the runner.
A clear alternative to consider is defense through upgrades. One can try to tax credits (Giordano Memorial Field) or cards (Hokusai Grid, Prisec) or both (Manegarm Skunkworks), but the new HB agenda Ontological Dependence really makes taxing the runner through inflicting core damage an effective strategy, with this card (Mr. Hendrik) and even a mostly meh card like Tempus synergizing together to compound its effects.
As Diogene mentions in the above review, Mr. Hendrik is most effective paired with itself, since the runner can only lose all their clicks once. But it also synergizes well with other cards and effects that sap the runner’s clicks like Manegarm Skunkworks and Tempus, and even Bioroid ice. Having multiple upgrades like this can create secure servers without any ice at all, or strengthen a server protected by Manegarm Skunkworks and Formicary. Multiple cards of this kind reduce the effectiveness of targeted interventions like Pinhole Threading, and an escalated response like Light the Fire! just feeds into your strategy to attack the runner.
I’ve found this works great as a support package for Sportsmetal: Go Big or Go Home, for punishing runners who aggressively check new servers and for creating fast advance opportunities with Ontological Dependence instead of Project Vitruvius.
Just remember that Mr. Hendrik and many cards that synergize with it like Tempus and (less effectively) Prisec require the corp to spend extra credits to land, so you have to keep your money at a sufficient level, sort of like making sure you have the credits to fire your Snare!.